By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc
This textbook explores the historical past, biology, and remedy of acid similar illnesses, together with gastric and duodenal ulcer illness, gastroesophageal reflux illness (GERD), and the function of H. pylori. The textual content bargains thorough assurance of the subject material, with an in-depth ancient and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the explicit disorder states of ulcers and GERD. This version is stuffed with new full-color clinical illustrations of all points of this topic.
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Additional resources for Acid Related Diseases: Biology and Treatment
Why the α subunit is unstable in the absence of the β subunit is not obvious, because the plasma membrane Ca2+ ATPase has similar topology but does not require a β subunit for stable plasma membrane expression. It seems that membrane insertion of the M5 and subsequent domains depends on expression of the β subunit. Only the K+ countertransport pumps require a β subunit, and modification of this protein modifies pump kinetics. The three isoforms of the Na+ pump are differentially expressed in various tissues, with, therefore, specialized functions.
There is one membrane-spanning region predicted by the hydropathy analysis, which is located at the region between positions 38 and 63 near the N terminus. Tryptic digestion of the intact gastric H,K ATPase produces only one small cleavage of the N-terminal segment of the β subunit on sodium dodecyl sulfate (SDS) gels. Wheat germ agglutinin (WGA) binding of the β subunit is retained due to the N-linked sugar residues. These data indicate that most of the β subunit is extracytoplasmic and glycosylated.
In: Johnson LR, ed. Physiology of the gastrointestinal tract, 2nd ed, vol 1. New York: Raven Press, 1987:817. Ito S, Schofield GC. Studies on the depletion and accumulation of microvilli and changes in the tubulovesicular compartment of mouse parietal cells in relation to gastric acid secretion. J Cell Biol 1974;63:364. Jewell EA, Lingrel JB. Site directed mutagenesis of the Na,K ATPase. Consequences of the substitutions of negatively charged amino acids localized in the transmembrane domains. Biochemistry 1993;32:13523-13530.
Acid Related Diseases: Biology and Treatment by Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc